Signaling Pathway Analysis through MetaCore™
In conjunction with Thomson Reuters, originally GeneGo, CF-specific multi-step canonical pathway maps are available through the MetaCore™ database. These CF disease maps were designed in conjunction with Cystic Fibrosis Foundation Therapeutics, Inc. and a committee of expert CF scientists based on manually curated primary literature.
Researchers can access literature references associated with elements in the pathway maps through direct links to PubMed. Researchers can browse, access, and export directly to EndNote or Excel information from the database to use in their research. The database is updated quarterly based on published literature.
The CF pathway maps in MetaCore depict key disease-causative and disease progressive mechanisms. MetaDrug™ and ToxHunter™ provide systems pharmacology platforms that can be used to predict human metabolites, toxicity and mode of action of small molecule drug compounds.
CF pathway maps cover:
- CFTR trafficking and folding
- Cholesterol and sphingolipids transport
- CF immune response
- Mucin expression in CF
- CFTR activation
- The effects of bacterial infections in CF airways
Researchers can build custom signaling networks from experimental data as well as overlay experimental data onto the CF pathway maps.
The pathway maps and networks may enable researchers to formulate and test hypotheses towards identifying novel disease biomarkers and drug target selection and validation.
The pathway maps are available from Life Sciences Research. Access to the full MetaCore platform requires a software subscription.