The Institute for Clinical and Economic Review (ICER) conducted an assessment of the clinical effectiveness and value of CFTR modulators including elexacaftor/tezacaftor/ivacaftor (Trikafta®), tezacaftor/ivacaftor (Symdeko®), lumacaftor/ivacaftor
(Orkambi®), and ivacaftor (Kalydeco®). ICER last reviewed CFTR modulators in May 2018.
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